首页
n/a
Article Publish Status: FREE

Abstract Title:

Acute Effects of the Consumption ofJuice on Metabolic Risk Factors and Gene Expression Profile in Humans.

Abstract Source:

Nutrients. 亿乐彩彩票 Apr 16 ;12(4). Epub 亿乐彩彩票 Apr 16. PMID:

Abstract Author(s):

Isabella de Araújo Esteves Duarte, Dragan Milenkovic, Tatiana Karla Dos Santos Borges, Artur Jordão de Magalhães Rosa, Christine Morand, Livia de Lacerda de Oliveira, Ana Maria Costa

Article Affiliation:

Isabella de Araújo Esteves Duarte

Abstract:

BACKGROUND: (PS) is a passionfruit variety of the Brazilian savannah and is a rich source of plant food bioactives with potential anti-inflammatory activity. This study aimed to investigate the effect of an acute intake of PS juice upon inflammation, metabolic parameters, and gene expression on circulating immune cells in humans.

METHODS: Overweight male volunteers (= 12) were enrolled in two double-blind placebo-controlled studies. Blood samples were collected from fasting volunteers 3 h after the consumption of 250 mL of PS juice or placebo (PB). Metabolic parameters (insulin, glucose, total cholesterol, high-density lipoprotein (LDL), high-density lipoprotein (HDL), and total triglycerides) and circulating cytokines were evaluated (study 1). Peripheral blood mononuclear cell (PBMC) from the same subjects were isolated and RNA was extracted for transcriptomic analyses using microarrays (study 2).

RESULTS: Insulin and 亿乐彩彩票ostatic model assessment for insulin resistance (HOMA-IR) levels decreased statistically after the PS juice intake, whereas HDL level increased significantly. Interleukin (IL)-17A level increased after placebo consumption, whereas its level remained unchanged after PS juice consumption. Nutrigenomic analyses revealed 1327 differentially expressed genes after PS consumption, with modulated genes involved in processes such as inflammation, cell adhesion, or cytokine-cytokine receptor.

CONCLUSION: Taken together, these clinical results support the hypothesis that PS consumption may help the prevention of cardiometabolic diseases.

Study Type : Human Study

Print Options


Key Research Topics

Sayer Ji
Founder of

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© 亿乐彩彩票 2008-亿乐彩彩票 , Journal Articles copyright of original owners, MeSH copyright NLM.