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Abstract Title:

Piceatannol-Loaded Emulsomes Exhibit Enhanced Cytostatic and Apoptotic Activities in Colon Cancer Cells.

Abstract Source:

Antioxidants (Basel). 亿乐彩彩票 May 13 ;9(5). Epub 亿乐彩彩票 May 13. PMID:

Abstract Author(s):

Nabil A Alhakamy, Shaimaa M Badr-Eldin, Osama A A Ahmed, Hani Z Asfour, Hibah M Aldawsari, Mardi M Algandaby, Basma G Eid, Ashraf B Abdel-Naim, Zuhier A Awan, Adel F Alghaith, Ahmed L Alaofi, Amir I Mohamed, Solomon Z Okbazghi, Mohammed W Al-Rabia, Usama A Fahmy

Article Affiliation:

Nabil A Alhakamy

Abstract:

Piceatannol (PIC), a naturally occurring polyphenolic stilbene, has pleiotropic pharmacological activities. It has reported cytotoxic activities against different cancer cells. In the present study, PIC emulsomes (PIC-E) were formulated and assessed for cytotoxic activity. A Box-Behnken design was employed to investigate the influence of formulation factors on particle size and drug entrapment. After optimization, the formulation had a spherical shape with a particle size of 125.45± 1.62 nm and entrapment efficiency of 93.14% ± 2.15%. Assessment of cytotoxic activities indicated that the optimized PIC-E formula exhibited significantly lower ICagainst HCT 116 cells. Analysis of the cell cycle revealed the accumulation of cells in the G2-M phase as well as increased cell fraction in the sub-G1 phase, an indication of apoptotic-enhancing activity. Staining of cells with Annexin V indicated increased early and late apoptosis. Further, the cellular contents of caspase - 3 andmRNA expression were significantly elevated by PIC-E. In addition, the mitochondrial membrane potential (MMP) was disturbed and reactive oxygen species (ROS) production was increased. In conclusion, PIC-E exhibited superior cell death-inducing activities against HCT 116 cells as compared to pure PIC. This is mediated, at least partly, by enhanced pro-apoptotic activity, disruption of MMP, and stimulation of ROS generation.

Study Type : In Vitro Study

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